Nakamura Lab

Toru M. Nakamura Publications
* (Corresponding Author)

Nakamura Lab [University of Illinois at Chicago, Oct. 2004 - present]
[23 research papers; 2 review papers; 1 book chapter]
Past & present lab members are highlighted with light blue.


39. Mennie, A.K., Moser, B.A., Hoyle, A., Low, R.S., Tanaka, K. and Nakamura, T.M.*
Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast.
Commun. Biol. 2:297. (doi:10.1038/s42003-019-0546-8) [pdf] [Supp. Data 1] [Supp. Data 2]

38. Xu, Y.-J.*, Khan, S., Didier, A.C., Wozniak, M., Liu, Y., Singh, A., and Nakamura, T.M.
A tel2 mutation that destabilizes the Tel2-Tti1-Tti2 (TTT) complex eliminates Rad3ATR kinase signaling in the DNA replication checkpoint and leads to telomere shortening in fission yeast.
Mol. Cell. Biol. (doi:10.1128/MCB.00175-19) [pdf]

37. Noguchi, C., Singh, T., Ziegler, M.A., Peake, J.D., Khair, L., Aza, A., Nakamura, T.M. and Noguchi, E.*
The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.
Epigenetics Chromatin 12(1):24. (doi:10.1186/s13072-019-0271-z) [pdf]


36. Matmati, S., Vaurs, M., Escandell, J.M., Maestroni, L., Nakamura, T.M., Ferreira, M.G., Géli, V.* and Coulon, S.*
The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.
Science Adv. 4(5): eaar2740. (doi:10.1126/sciadv.aar2740) [pdf]

35. Mennie, A.K., Moser, B.A. and Nakamura, T.M.*
LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.
Nature Commun. 9(1): 586. (doi:10.1038/s41467-018-02874-0) [pdf] [Supp. Data 1]


34. Nie, M., Moser, B.A., Nakamura, T.M. and Boddy, M.N. *
SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.
PLoS Genet. 13(5): e1006776. (doi:10.1371/journal.pgen.1006776) [pdf]
[evaluated by Faculty of 1000]


33. Gadaleta, M.C., Das, M.M., Tanizawa, H., Chang, Y.-T., Noma, K.I., Nakamura, T.M. and Noguchi, E.*
Swi1Timeless prevents repeat instability at fission yeast telomeres.
PLoS Genet. 12(3): e1005943. (doi:10.1371/journal.pgen.1005943) [pdf]


32. Moser, B.A., Raguimova, O.N. and Nakamura, T.M.*
Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast.
Mol. Biol. Cell 26(21): 3857-3866. (doi:10.1091/mbc.E15-07-0531) [pdf]

31. Audry, J., Maestroni, L., Delagoutte, E., Gauthier, T., Nakamura, T.M., Gachet, Y., Saintome, C., Géli, V.* and Coulon, S.*
RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.
EMBO J. 34(14): 1942-1958. (doi:10.15252/embj.201490773) [pdf]


30. Harland, J.L., Chang, Y.-T., Moser, B.A. and Nakamura, T.M.*
Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.
PLoS Genet. 10(10): e1004708. (doi:10.1371/journal.pgen.1004708) [pdf]

29. Miyagawa, K., Low, R.S., Santosa, V., Tsuji, H., Moser, B.A., Fujisawa, S., Harland, J.L., Raguimova, O.N., Go, A., Ueno, M., Matsuyama, A., Yoshida, M., Nakamura, T.M.* and Tanaka, K.*
SUMOylation regulates telomere length by targeting Tpz1TPP1 to modulate shelterin-Stn1 interaction in fission yeast.
Proc. Natl. Acad. Sci. U.S.A. 111(16): 5950-5955. (doi:10.1073/pnas.1401359111) [pdf]

28. Moser, B.A., Chang, Y.-T. and Nakamura, T.M.*
Telomere regulation during cell cycle in fission yeast. (Protocol / Book chapter)
Methods Mol. Biol. 1170:411-424. (doi:10.1007/978-1-4939-0888-2_22) [pdf]


27. Chang, Y.-T., Moser, B.A. and Nakamura, T.M.*
Fission yeast shelterin regulates DNA polymerases and Rad3ATR kinase to limit telomere extension.
PLoS Genet. 9(11): e1003936. (doi:10.1371/journal.pgen.1003936) [pdf]


26. Garabedian, M.V., Noguchi, C., Ziegler, M.A., Das, M.M., Singh, T., Harper, L.J., Leman, A.R., Khair, L., Moser, B.A., Nakamura, T.M. and Noguchi, E.*
The double-bromodomain factors Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.
Genetics 190: 487-500. (doi:10.1534/genetics.111.135459) [pdf]


25. Moser, B.A., Chang, Y.-T., Kosti, J. and Nakamura, T.M.*
Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.
Nature Struct. Mol. Biol. 18: 1408-1413. (doi:10.1038/nsmb.2187) [pdf]
[evaluated by Faculty of 1000]


24. Carneiro, T., Khair, L., Reis, C.C., Borges, V., Moser, B.A., Nakamura, T.M. and Ferreira, M.G.*
Telomeres avoid end detection by severing the checkpoint signal transduction pathway.
Nature 467(7312): 228-232
. (doi:10.1038/nature09353) [pdf]
[evaluated by Faculty of 1000]

23. Jain, D., Hebden, A.K., Nakamura, T.M., Miller, K.M. and Cooper, J.P.*
HAATI survivors replace canonical telomeres with blocks of generic heterochromatin.
Nature 467(7312): 223-227
. (doi:10.1038/nature09374) [pdf]

22. Subramanian, L. and Nakamura, T.M.*
To fuse or not to fuse: How do checkpoint and DNA repair proteins maintain telomeres? (Review)
Front. Biosci. 15: 1105-1118
. (doi:10.2741/3664) [pdf]

21. Khair, L., Chang, Y.-T., Subramanian, L., Russell, P. and Nakamura, T.M.*
Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.
Cell Cycle 9(11): 2237-2248
. (doi:10.4161/cc.9.11.11920) [pdf]

20. Subramanian, L. and Nakamura, T.M.*
A kinase-independent role for the Rad3ATR-Rad26ATRIP complex in recruitment of Tel1ATM to telomeres in fission yeast.
PLoS Genet. 6(2): e1000839
. (doi:10.1371/journal.pgen.1000839) [pdf]

19. Khair, L., Subramanian, L., Moser, B.A. and Nakamura, T.M.*
Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.
J. Biol. Chem. 285(8): 5327-5337
. (doi:10.1074/jbc.M109.078840) [pdf]


18. Moser, B.A., Subramanian, L., Khair, L., Chang, Y.-T. and Nakamura, T.M.*
Fission yeast Tel1ATM and Rad3ATR promote telomere protection and telomerase recruitment.
PLoS Genet. 5(8): e1000622
. (doi:10.1371/journal.pgen.1000622) [pdf]
[evaluated by Faculty of 1000]

17. Moser, B.A. and Nakamura, T.M.*
Protection and replication of telomeres in fission yeast. (Review)
Biochem. Cell Biol. 87(5): 747-758
. (doi:10.1139/O09-037) [pdf]

16. Moser, B.A., Subramanian, L., Chang, Y.-T., Noguchi, C., Noguchi, E. and Nakamura, T.M.*
Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.
EMBO J. 28(7): 810-820
. (doi:10.1038/emboj.2009.31) [pdf]
["Have you seen...?" by C.M. Price] [evaluated by Faculty of 1000]


15. Subramanian, L., Moser, B.A. and Nakamura, T.M.*
Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1, and inhibited by telomerase, Taz1 and Ku in fission yeast.
Mol. Cell. Biol. 28(5): 1443-1455
. (doi:10.1128/MCB.01614-07) [pdf]

14. Ansbach, A.B., Noguchi, C., Klansek, I.W., Heidlebaugh, M., Nakamura, T.M. and Noguchi, E.*
RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
Mol. Biol. Cell 19(2): 595-607
. (doi:10.1091/mbc.E07-06-0618) [pdf]

Postdoctral Works [Russell Lab, The Scripps Research Institute, Nov. 1999 - Sept. 2004]
[7 research papers]


13. Du, L.-L., Nakamura, T.M. and Russell, P.*
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.
Genes Dev. 20(12): 1583-1596
. (doi:10.1101/gad.1422606) [pdf]
[evaluated by Faculty of 1000]

12. Coulon, S., Noguchi, E., Noguchi, C., Du, L.-L., Nakamura, T.M. and Russell, P.*
Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.
Mol. Biol. Cell 17(4): 2081-2090
. (doi:10.1091/mbc.E05-11-1006) [pdf]


11. Nakamura, T.M.*, Moser, B.A., Du, L.-L. and Russell, P.*
Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.
Mol. Cell. Biol. 25(24): 10721-10730
. (doi:10.1128/MCB.25.24.10721-10730.2005) [pdf]


10. Nakamura, T.M.*, Du, L.-L., Redon, C. and Russell, P.*
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest and influences DNA repair in fission yeast.
Mol. Cell. Biol. 24(14): 6215-6230
. (doi:10.1128/MCB.24.14.6215-6230.2004) [pdf]


9. Chahwan, C., Nakamura, T.M., Sivakumar, S., Russell, P. and Rhind, N.*
The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-Phase DNA damage checkpoint.
Mol. Cell. Biol. 23(18): 6564-6573
. (doi:10.1128/MCB.23.18.6564-6573.2003) [pdf]

8. Du, L.-L., Nakamura, T.M., Moser, B.A. and Russell, P.*
Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.
Mol. Cell. Biol. 23(17): 6150-6158
. (doi:10.1128/MCB.23.17.6150-6158.2003) [pdf]
[evaluated by Faculty of 1000]


7. Nakamura, T.M.*, Moser, B.A. and Russell, P.
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Genetics 161(4): 1437-1452
. [Full Text] [pdf]

Graduate School [Cech Lab, University of Colorado at Boulder, Aug. 1993 - Oct. 1999]
[4 research papers; 2 review papers]


6. Haering, C.H., Nakamura, T.M., Baumann, P. and Cech, T.R.*
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe.
Proc. Natl. Acad. Sci. U.S.A. 97(12): 6367-72
. (doi:10.1073/pnas.130187397) [pdf]


5. Nakamura, T.M., Cooper, J.P. and Cech, T.R.*
Two modes of survival of fission yeast without telomerase.
Science 282(5388): 493-496
. (doi:10.1126/science.282.5388.493) [pdf]

4. Nakamura, T.M.* and Cech, T.R.
Reversing time: origin of telomerase. (Review)
Cell 92(5): 587-590
. (doi:10.1016/S0092-8674(00)81123-X) [pdf]


3. Cech, T.R.*, Nakamura, T.M. and Lingner, J.
Telomerase is a true reverse transcriptase. (Review)
Biochemistry (Moscow) 62(11): 1202-1205
. [Full Text ] [pdf]

2. Nakamura, T.M., Morin, G.B., Chapman, K.B., Weinrich, S.L., Andrews, W.H., Lingner, J., Harley, C.B. and Cech. T.R.*
Telomerase catalytic subunit homologs from fission yeast and human.
Science 277(5328): 955-959
. (doi:10.1126/science.277.5328.955) [pdf]
[Perspective by T.E. Eickbush]


1. Nakamura, T.M., Wang, Y.-H., Zaug, A.J., Griffith, J.D. and Cech, T.R.*
Relative orientation of RNA helices in a Group I ribozyme determined by helix extension electron microscopy.
EMBO J. 14(19): 4849-4859
. [pdf]

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Last modified on Aug. 7, 2019